Description：

KPT-276 is an orally bioavailable selective CRM1 inhibitor.

Chemical Information：

Molecular Weight (MW)		426.26
Formula		C16H10F8N4O
CAS No.		1421919-75-6
Solubility (25°C) *	DMSO	20 mg/mL (46.91 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

CDK9 CDK1 CDK4 20 nM 79 nM 63 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3460 mL	11.7299 mL	23.4599 mL
5 mM	0.4692 mL	2.3460 mL	4.6920 mL
10 mM	0.2346 mL	1.1730 mL	2.3460 mL
50 mM	0.0469 mL	0.2346 mL	0.4692 mL

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