Description：

KN-62 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.9 μM; also a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM). It is selective for CaMKII relative to PKA, PKC and MLCK, but inhibits CaMKI and CaMKIV equally well, The Ki value of KN-62 for CaMK V is 0.8 μM.

Chemical Information：

Molecular Weight (MW)		721.84
Formula		C38H35N5O6S2
CAS No.		127191-97-3
Solubility (25°C) *	DMSO	100 mg/mL (138.53 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

ATR 14 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.3853 mL	6.9267 mL	13.8535 mL
5 mM	0.2771 mL	1.3853 mL	2.7707 mL
10 mM	0.1385 mL	0.6927 mL	1.3853 mL
50 mM	0.0277 mL	0.1385 mL	0.2771 mL

Bought notes(bought amounts latest0)

No one bought this product

Total 0 records, divided into1 pages. First Prev Next Last