Description：

Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with K_i of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activity at LPA4, LPA5, LPA6.

Chemical Information：

Molecular Weight (MW)		488.98
Formula		C24H25ClN2O5S
CAS No.		355025-13-7
Solubility (25°C) *	DMSO	96 mg/mL (196.32 mM)
	Water	Insoluble
	Alcohol	35 mg/mL (71.57 mM)

Biological Activity：

Targets IC50

PI3Kα PI3Kβ DNA-PK PI3Kδ 4 nM 0.5 nM 8.6 nM 0.1 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0451 mL	10.2254 mL	20.4507 mL
5 mM	0.4090 mL	2.0451 mL	4.0901 mL
10 mM	0.2045 mL	1.0225 mL	2.0451 mL
50 mM	0.0409 mL	0.2045 mL	0.4090 mL

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