Description：

JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.

Chemical Information：

Molecular Weight (MW)		394.36
Formula		C15H12F2N6O3S
CAS No.		443797-96-4
Solubility (25°C) *	DMSO	79 mg/mL (200.32 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

PDGFR 0.3-0.5 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.5358 mL	12.6788 mL	25.3575 mL
5 mM	0.5072 mL	2.5358 mL	5.0715 mL
10 mM	0.2536 mL	1.2679 mL	2.5358 mL
50 mM	0.0507 mL	0.2536 mL	0.5072 mL

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