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JNJ-26854165 (Serdemetan)

JNJ-26854165 (Serdemetan)

Catalog Number: CC1328 Rank: comment rank 5

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Description:

JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.

Chemical Information:

Molecular Weight (MW) 328.41
Formula

 

C21H20N4

 

CAS No. 881202-45-5
Solubility (25°C) * DMSO 66 mg/mL (200.96 mM)
Water Insoluble
Alcohol 2 mg/mL (6.08 mM)


Biological Activity:

Targets
IC50
SGLT2
3.1 nM


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 3.0450 mL 15.2249 mL 30.4497 mL
5 mM 0.6090 mL 3.0450 mL 6.0899 mL
10 mM 0.3045 mL 1.5225 mL 3.0450 mL
50 mM 0.0609 mL 0.3045 mL 0.6090 mL


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