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Description:
JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.
Chemical Information:
Molecular Weight (MW) 328.41 Formula
C21H20N4
CAS No. 881202-45-5 Solubility (25°C) * DMSO 66 mg/mL (200.96 mM) Water Insoluble Alcohol 2 mg/mL (6.08 mM)
Biological Activity:
Targets IC50
SGLT2 3.1 nM
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg 1 mM 3.0450 mL 15.2249 mL 30.4497 mL 5 mM 0.6090 mL 3.0450 mL 6.0899 mL 10 mM 0.3045 mL 1.5225 mL 3.0450 mL 50 mM 0.0609 mL 0.3045 mL 0.6090 mL
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