Description：

Jervine is an inhibitor of Hedgehog signaling (IC50=500-700 nM) that inhibits the sonic hedgehog (shh) pathway by interacting with smoothened.

Chemical Information：

Molecular Weight (MW)		425.60
Formula		C27H39NO3
CAS No.		469-59-0
Solubility (25°C) *	DMSO	5 mg/mL (11.74 mM)
	Water	Insoluble
	Alcohol	2 mg/mL (4.69 mM)

Biological Activity：

Targets IC50

Akt1 Akt3 Akt2 3 nM 8 nM 8 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3496 mL	11.7481 mL	23.4962 mL
5 mM	0.4699 mL	2.3496 mL	4.6992 mL
10 mM	0.2350 mL	1.1748 mL	2.3496 mL
50 mM	0.0470 mL	0.2350 mL	0.4699 mL

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