Description：

(+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family.

Chemical Information：

Molecular Weight (MW)		456.99
Formula		C23H25ClN4O2S
CAS No.		1268524-70-4
Solubility (25°C) *	DMSO	91 mg/mL warmed (199.12 mM)
	Water	Insoluble
	Alcohol	91 mg/mL (199.12 mM)

Biological Activity：

Targets IC50

BRAF(V600E) Abl-1 CSF-1R c-Raf BRAF(WT) 14 nM 3 nM 9 nM 39 nM 36 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1882 mL	10.9412 mL	21.8823 mL
5 mM	0.4376 mL	2.1882 mL	4.3765 mL
10 mM	0.2188 mL	1.0941 mL	2.1882 mL
50 mM	0.0438 mL	0.2188 mL	0.4376 mL

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