Description：

Ixazomib Citrate (MLN9708) immediately hydrolyzed to MLN2238, the biologically active form, on exposure to aqueous solutions or plasma. MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/K_i of 3.4 nM/0.93 nM in cell-free assays, less potent to β1 and little activity to β2. Phase 3.

Chemical Information：

Molecular Weight (MW)		517.12
Formula		C20H23BCl2N2O9
CAS No.		1201902-80-8
Solubility (25°C) *	DMSO	100 mg/mL (193.37 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

GPR40 GPR120 7.32 (pEC50) 5.46 (pEC50) [1

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9338 mL	9.6689 mL	19.3379 mL
5 mM	0.3868 mL	1.9338 mL	3.8676 mL
10 mM	0.1934 mL	0.9669 mL	1.9338 mL
50 mM	0.0387 mL	0.1934 mL	0.3868 mL

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