Description：

ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM and does not have global effects on translation, transcription, or mRNA stability in non-stressed cells.

Chemical Information：

Molecular Weight (MW)		451.34
Formula		C22H24Cl2N2O4
CAS No.		1597403-47-8
Solubility (25°C) *	DMSO	4 mg/mL (8.86 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

Pyk2 FAK 14 nM 1.5 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2156 mL	11.0781 mL	22.1562 mL
5 mM	0.4431 mL	2.2156 mL	4.4312 mL
10 mM	0.2216 mL	1.1078 mL	2.2156 mL
50 mM	0.0443 mL	0.2216 mL	0.4431 mL

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