Description：

Ispinesib (SB-715992) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with K_{i app} of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A. Phase 2.

Chemical Information：

Molecular Weight (MW)		517.06
Formula		C30H33ClN4O2
CAS No.		336113-53-2
Solubility (25°C) *	DMSO	103 mg/mL (199.2 mM)
	Water	Insoluble
	Alcohol	103 mg/mL (199.2 mM)

Biological Activity：

Targets IC50

NF-κB 7.1 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9340 mL	9.6701 mL	19.3401 mL
5 mM	0.3868 mL	1.9340 mL	3.8680 mL
10 mM	0.1934 mL	0.9670 mL	1.9340 mL
50 mM	0.0387 mL	0.1934 mL	0.3868 mL

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