Description：

Ipatasertib (GDC-0068) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, 620-fold selectivity over PKA. Phase 2.

Chemical Information：

Molecular Weight (MW)		458
Formula		C24H32ClN5O2
CAS No.		1001264-89-6
Solubility (25°C) *	DMSO	92 mg/mL (200.87 mM)
	Water	Insoluble
	Alcohol	92 mg/mL (200.87 mM)

Biological Activity：

Targets IC50

EGFRL858R/T790M EGFRWT 21.5 nM (Ki) 303.3 nM (Ki)[1

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1834 mL	10.9170 mL	21.8341 mL
5 mM	0.4367 mL	2.1834 mL	4.3668 mL
10 mM	0.2183 mL	1.0917 mL	2.1834 mL
50 mM	0.0437 mL	0.2183 mL	0.4367 mL

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