Description：

IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.

Chemical Information：

Molecular Weight (MW)		352.34
Formula		C19H16N2O5
CAS No.		931398-72-0
Solubility (25°C) *	DMSO	7 mg/mL (19.86 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

OX1 receptor OX2 receptor 0.55 nM (Ki) 0.35 nM (Ki) [1

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.8382 mL	14.1908 mL	28.3817 mL
5 mM	0.5676 mL	2.8382 mL	5.6763 mL
10 mM	0.2838 mL	1.4191 mL	2.8382 mL
50 mM	0.0568 mL	0.2838 mL	0.5676 mL

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