Description：

Icotinib is a potent and specific EGFR inhibitor with IC50 of 5 nM, including the EGFR, EGFR(L858R), EGFR(L861Q), EGFR(T790M) and EGFR(T790M, L858R).

Chemical Information：

Molecular Weight (MW)		391.42
Formula		C22H21N3O4
CAS No.		610798-31-7
Solubility (25°C) *	DMSO	78 mg/mL (199.27 mM)
	Water	Insoluble
	Alcohol	7 mg/mL (17.88 mM)

Biological Activity：

Targets IC50

EZH1 EZH2 45 nM 2 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.5548 mL	12.7740 mL	25.5480 mL
5 mM	0.5110 mL	2.5548 mL	5.1096 mL
10 mM	0.2555 mL	1.2774 mL	2.5548 mL
50 mM	0.0511 mL	0.2555 mL	0.5110 mL

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