Description：

Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.

Chemical Information：

Molecular Weight (MW)		440.5
Formula		C25H24N6O2
CAS No.		936563-96-1
Solubility (25°C) *	DMSO	88 mg/mL (199.77 mM)
	Water	Insoluble
	Alcohol	45 mg/mL (102.15 mM)

Biological Activity：

Targets IC50

P300/CBP 400 nM (Ki)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2701 mL	11.3507 mL	22.7015 mL
5 mM	0.4540 mL	2.2701 mL	4.5403 mL
10 mM	0.2270 mL	1.1351 mL	2.2701 mL
50 mM	0.0454 mL	0.2270 mL	0.4540 mL

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