Description：

Hydroxyfasudil (HA-1100), an active metabolite of fasudil hydrochloride, is a specific Rho-kinase(ROCK) inhibitor with IC50 values of 0.73 μM and 0.72 μM for ROCK1 and ROCK2, respectively.

Chemical Information：

Molecular Weight (MW)		343.83
Formula		C14H17N3O3S·HCl·xH2O
CAS No.		155558-32-0 (HCl salt)
Solubility (25°C) *	DMSO	68 mg/mL warmed (197.77 mM)
	Water	60 mg/mL warmed (174.5 mM)
	Alcohol	Insoluble

Biological Activity：

Targets IC50

EZH2 EZH2 11 nM 2.5 nM (Ki)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.9084 mL	14.5421 mL	29.0841 mL
5 mM	0.5817 mL	2.9084 mL	5.8168 mL
10 mM	0.2908 mL	1.4542 mL	2.9084 mL
50 mM	0.0582 mL	0.2908 mL	0.5817 mL

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