Description：

Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with K_d of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Phase 3.

Chemical Information：

Molecular Weight (MW)		440.29
Formula		C18H19O8P.2Na
CAS No.		168555-66-6
Solubility (25°C) *	DMSO	Insoluble
	Water	28 mg/mL (63.59 mM)
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2712 mL	11.3562 mL	22.7123 mL
5 mM	0.4542 mL	2.2712 mL	4.5425 mL
10 mM	0.2271 mL	1.1356 mL	2.2712 mL
50 mM	0.0454 mL	0.2271 mL	0.4542 mL

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