Description：

Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.

Chemical Information：

Molecular Weight (MW)		632.65
Formula		C34H34F2N4O6
CAS No.		849217-64-7
Solubility (25°C) *	DMSO	100 mg/mL (158.06 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.5807 mL	7.9033 mL	15.8065 mL
5 mM	0.3161 mL	1.5807 mL	3.1613 mL
10 mM	0.1581 mL	0.7903 mL	1.5807 mL
50 mM	0.0316 mL	0.1581 mL	0.3161 mL

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