Description：

Fedratinib (SAR302503, TG101348) is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Phase 2.

Chemical Information：

Molecular Weight (MW)		524.68
Formula		C27H36N6O3S
CAS No.		936091-26-8
Solubility (25°C) *	DMSO	100 mg/mL (190.59 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

COX-1 COX-2 0.25 μM 0.15 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9059 mL	9.5296 mL	19.0592 mL
5 mM	0.3812 mL	1.9059 mL	3.8118 mL
10 mM	0.1906 mL	0.9530 mL	1.9059 mL
50 mM	0.0381 mL	0.1906 mL	0.3812 mL

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