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1-Azakenpaullone

Catalog Number: CC7349 Rank: comment rank 5

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Description:

1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.

Chemical Information:

Molecular Weight (MW) 328.16
Formula

 

C15 H10 Br N3 O

 

CAS No. 676596-65-9
Solubility (25°C) * DMSO 66 mg/mL (201.12 mM)
Water Insoluble
Alcohol Insoluble


Biological Activity:

Targets
IC50
Bcl-xL Bcl-2 Bcl-w
≤ 0.5 nM (Ki) ≤1 nM (Ki) ≤ 1 nM (Ki)


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 3.0473 mL 15.2365 mL 30.4729 mL
5 mM 0.6095 mL 3.0473 mL 6.0946 mL
10 mM 0.3047 mL 1.5236 mL 3.0473 mL
50 mM 0.0609 mL 0.3047 mL 0.6095 mL


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